Diamond B J, Kim H, DeLuca J, Cordero D L
Kessler Institute for Rehabilitation, Department of Research, West Orange, New Jersey 07052, USA.
Mult Scler. 1995 Nov;1(3):156-62. doi: 10.1177/135245859500100304.
Traditional assessments of autonomic nervous system function have depended on invasive and complex procedures. Vagal power, which is the respiratory component of heart rate variability (HRV) is an alternative and non-invasive measure for indexing autonomic nervous control of the heart. In the current study, 18 multiple sclerosis (MS) and 20 healthy subjects matched with respect to age, education and intelligence served as subjects. The MS group showed significantly lower vagal power during natural and paced breathing than healthy subjects. Importantly, heart rate did not differ between the two groups. If MS patients exhibit abnormalities in mechanisms mediating cardiac parasympathetic control, the impact on quality of life and vulnerability to adverse cardiac events need to be further evaluated. The results of this study may have implications with respect to the feasibility of using HRV as both a diagnostic and prognostic tool for evaluating parasympathetic nervous system dysfunction and in providing valuable information for developing more effective treatment and rehabilitation strategies.
传统的自主神经系统功能评估依赖于侵入性和复杂的程序。迷走神经张力是心率变异性（HRV）的呼吸成分，是一种用于衡量心脏自主神经控制的替代性非侵入性指标。在本研究中，选取了18名多发性硬化症（MS）患者和20名在年龄、教育程度和智力方面相匹配的健康受试者作为研究对象。MS组在自然呼吸和定频呼吸时的迷走神经张力显著低于健康受试者。重要的是，两组之间的心率没有差异。如果MS患者在介导心脏副交感神经控制的机制方面表现出异常，那么对生活质量的影响以及发生不良心脏事件的易感性需要进一步评估。本研究结果可能对将HRV用作评估副交感神经系统功能障碍的诊断和预后工具的可行性具有启示意义，并为制定更有效的治疗和康复策略提供有价值的信息。
