Goldberg T E, Berman K F, Randolph C, Gold J M, Weinberger D R
Clinical Brain Disorders Branch, NIMH, NIH, NIMH Neurosciences Center at St. Elizabeths, Washington, DC 20032, USA.
Neuroimage. 1996 Feb;3(1):69-78. doi: 10.1006/nimg.1996.0008.
In this study we attempted to elucidate the neural network involved in maintaining spatial information over short delays by means of the PET 15O-labeled water method for measuring regional cerebral blood flow. To isolate the mnemonic component of delayed response processing we designed a control task isomorphic to the experimental task (in which the subject remembered the location of four targets in an array over a 7 s delay) and controlled for spatial encoding. Fourteen normal subjects participated in the study. Regional cerebral blood flow (rCBF) data were analyzed using statistical parametric mapping, a data-driven approach which canvasses the whole brain for significantly activated pixels in the experimental vis-à-vis the control task, and a hypothesis driven region of interest approach involving comparisons of control and experimental conditions using normalized rCBF data. We found convergent evidence for a spatially distinct but functionally related network in which dorsolateral prefrontal cortex and extrastriate occipital cortex were activated by the experimental task vis-à-vis the control task, as well as evidence for superior parietal and supplementary motor area cortical activation. These findings suggest that anterior components of the network may be involved in mnemonic rehearsal functions, while posterior components may store critical perceptual attributes of the memoranda.
在本研究中，我们试图通过正电子发射断层扫描（PET）的15O标记水法来测量局部脑血流量，以阐明参与在短延迟期间维持空间信息的神经网络。为了分离延迟反应处理中的记忆成分，我们设计了一个与实验任务同构的对照任务（在该任务中，受试者在7秒延迟期间记住阵列中四个目标的位置），并对空间编码进行了控制。14名正常受试者参与了该研究。使用统计参数映射分析局部脑血流量（rCBF）数据，这是一种数据驱动的方法，可在整个大脑中寻找实验任务与对照任务相比有显著激活像素的区域，以及一种假设驱动的感兴趣区域方法，该方法使用标准化的rCBF数据比较对照和实验条件。我们发现了一个空间上不同但功能相关的网络的收敛证据，其中背外侧前额叶皮层和枕叶纹外皮层在实验任务与对照任务相比时被激活，同时也发现了顶上叶和辅助运动区皮层激活的证据。这些发现表明，该网络的前部成分可能参与记忆复述功能，而后部成分可能存储记忆的关键感知属性。
