Seidler R D, Purushotham A, Kim S-G, Ugurbil K, Willingham D, Ashe J
Brain Sciences Center (11B), VAMC, One Veterans Drive, Minneapolis, MN 55417, USA.
Exp Brain Res. 2005 Aug;165(1):114-24. doi: 10.1007/s00221-005-2284-z. Epub 2005 Jun 18.
In the domain of motor learning it has been difficult to separate the neural substrate of encoding from that of change in performance. Consequently, it has not been clear whether motor effector areas participate in learning or merely modulate changes in performance. Here, using a variant of the serial reaction time task that dissociated these two factors, we report that encoding during procedural motor learning does engage cortical motor areas and can be characterized by distinct early and late encoding phases. The highest correlation between activation and subsequent changes in motor performance was seen in the motor cortex during early encoding, and in the basal ganglia during the late encoding phase. Our results show that rapid encoding during procedural motor learning involves several distinct processes, and is represented primarily within motor system structures.
在运动学习领域，一直难以将编码的神经基质与表现变化的神经基质区分开来。因此，尚不清楚运动效应器区域是参与学习还是仅仅调节表现的变化。在这里，我们使用一种串行反应时任务的变体来分离这两个因素，我们报告称，程序性运动学习过程中的编码确实涉及皮层运动区域，并且可以通过不同的早期和晚期编码阶段来表征。在早期编码期间，运动皮层中激活与随后运动表现变化之间的相关性最高，而在晚期编码阶段，基底神经节中的相关性最高。我们的结果表明，程序性运动学习过程中的快速编码涉及几个不同的过程，并且主要在运动系统结构中体现。
