Huntley C C, Lyerly A D, Littlejohn M P, Rodriguez-Trias H, Bowers G W
Pediatrics. 1976 Jun;57(6):875-83.
A prospective study was carried out at the University of Puerto Rico Hospital (UPRH) and at the North Carolina Baptist Hospital (NCBH) in order to establish the incidence of ABO hemolytic disease (ABO HD) in the two populations and to determine the relationship of intestinal parasitic infection of the mother to ABO HD in the infant. The incidence of ABO HD among UPRH at risk pregnancies (type O mother with type A or B infant) was 28.3% or 1 in 3.5 as compared with 18.4% or 1 in 5.4 of NCBH at risk pregnancies (P less than .05). Indirect Coombs' tests in cord sera, representing the passive transfer from mother to fetus of antibodies directed toward antigens on the infants' erythrocytes, were positive in 58.8% of UPRH at risk infants as opposed to 40.4% of NCBH at risk infants (P less than .001). Maternal isohemagglutinin titers at term were higher in type O UPRH mothers than in type O NCBH mothers (P less than .01). A relationship between helminth parasitic infection of the mother and ABO HD in the infant was suspected but not proved.
在波多黎各大学医院（UPRH）和北卡罗来纳浸信会医院（NCBH）开展了一项前瞻性研究，以确定这两个人群中ABO溶血病（ABO HD）的发病率，并确定母亲肠道寄生虫感染与婴儿ABO HD之间的关系。UPRH有风险妊娠（O型母亲与A型或B型婴儿）中ABO HD的发病率为28.3%，即3.5例中有1例，而NCBH有风险妊娠的发病率为18.4%，即5.4例中有1例（P<0.05）。脐血血清中的间接抗人球蛋白试验代表抗体从母亲被动转移至胎儿，针对婴儿红细胞上的抗原，UPRH有风险婴儿中58.8%呈阳性，而NCBH有风险婴儿中为40.4%（P<0.001）。足月时，UPRH的O型母亲的母体同种血凝素滴度高于NCBH的O型母亲（P<0.01）。怀疑母亲的蠕虫寄生虫感染与婴儿的ABO HD之间存在关系，但未得到证实。
