Karjoo M, McCarthy B
Pediatrics. 1976 Jun;57(6):962-6.
A 12-week-old white male infant with ulcerative colitis and toxic megacolon is described. His diarrhea and rectal bleeding responded to prednisone. He subsequently developed toxic dilatation of the transverse colon while on salicylazosulfapyridine and one week after discontinuation of prednisone. His toxic megacolon disappeared during close medical observation, readministration of prednisone, and avoidance of repeated abdominal examinations. One year later sigmoidoscopy showed only friable mucosa and the barium enema showed the presence of ulcerative colitis but with improvement from the initial study. Currently he is taking 375 mg of salicylazosulfapyridine daily. Growth and development are normal and he is asymptomatic.
本文描述了一名12周大的患有溃疡性结肠炎和中毒性巨结肠的白人男婴。他的腹泻和直肠出血对泼尼松有反应。随后，在服用柳氮磺胺吡啶期间以及停用泼尼松一周后，他出现了横结肠的中毒性扩张。在密切的医学观察、重新使用泼尼松以及避免反复进行腹部检查期间，他的中毒性巨结肠消失了。一年后，乙状结肠镜检查仅显示黏膜易碎，钡灌肠显示存在溃疡性结肠炎，但与最初的检查相比有所改善。目前，他每天服用375毫克柳氮磺胺吡啶。生长发育正常，且无症状。
