Caranza R, Raphael J H, Nandwani N, Langton J A
University Department of Anaesthesia, Leicester Royal Infirmary, UK.
Anaesthesia. 1997 Sep;52(9):849-52. doi: 10.1111/j.1365-2044.1997.200-az0335.x.
We have assessed the effect of nebulised lignocaine, given pre-operatively, upon the quality of induction of anaesthesia in cigarette smokers. Seventy-five patients were studied in a double-blind randomised fashion, receiving a nebuliser of either 4 ml 0.9% NaCl or 4 ml 4% lignocaine. All patients received a standardised anaesthetic consisting of thiopentone followed by progressive increments of enflurane. Thirty-three out of 38 patients (87%) who received nebulised lignocaine had induction without adverse events, compared with 25 out of 37 patients (68%) in the nebulised saline group (Chi-squared test p < 0.05). We conclude that the use of nebulised lignocaine, administered pre-operatively, improves the quality of induction of anaesthesia in cigarette smokers.
我们评估了术前雾化吸入利多卡因对吸烟患者麻醉诱导质量的影响。采用双盲随机方式对75例患者进行研究，患者分别接受4ml 0.9%氯化钠溶液或4ml 4%利多卡因的雾化吸入。所有患者均接受由硫喷妥钠诱导随后逐步增加恩氟烷浓度的标准化麻醉。接受雾化吸入利多卡因的38例患者中有33例（87%）诱导过程无不良事件，相比之下，雾化吸入生理盐水组的37例患者中有25例（68%）无不良事件（卡方检验p<0.05）。我们得出结论，术前使用雾化吸入利多卡因可改善吸烟患者的麻醉诱导质量。
