Gorban' E N, Neshcheret A P, Khomaziuk A I, Shurupova E N, Iakusheva L F
Probl Endokrinol (Mosk). 1976 May-Jun;22(3):91-4.
Development of alloxan diabetes was accompanied in dogs by regular changes in the phasic structure of the cardiac contractions. Direction of the changes in the indices of phasic analysis in the groups of dogs with an average (up to 144.3 +/- 12.5 mg%) and marked (up to 258.0 +/- 22.8 mg%) increase in the blood sugar level was the same, but their expression increased with the elevation of hyperglycemia. In marked hyperglycemia there was established an increase (in comparison with normal values) of the index of myocardial tension, a shortening of the period of ejection, a decrease of the mechanical coefficient and of the intrasystolic index, this coinciding with the character of changes of the corresponding indices in the patients suffering from diabetes mellitus, depending on the severity of the disease. The data obtained pointed to the significant influence of metabolic changes (assessed by hyperglycemia level) on the contractile function of the heart.
在狗身上，四氧嘧啶糖尿病的发展伴随着心脏收缩相位结构的规律性变化。血糖水平平均升高（高达144.3±12.5毫克%）和显著升高（高达258.0±22.8毫克%）的狗组中，相位分析指标的变化方向相同，但随着高血糖程度的升高，其表现有所增强。在显著高血糖状态下，与正常值相比，心肌张力指数增加、射血期缩短、机械系数和收缩期内指数降低，这与糖尿病患者相应指标的变化特征相符，且取决于疾病的严重程度。所获得的数据表明代谢变化（通过高血糖水平评估）对心脏收缩功能有显著影响。
