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[胰岛素缺乏在几种脂质代谢紊乱发病机制中的作用]

[The role of insulin deficit in the pathogenesis of several lipid metabolism disorders].

作者信息

Kantardzhian I G

出版信息

Probl Endokrinol (Mosk). 1976 May-Jun;22(3):95-9.

PMID:935100
Abstract

Alloxan diabetes of various degree of severity was accompanied in rabbits by an increase in cholesterol and triglyceride level and, also by a progressive increase in the concentration of prebeta-lipoproteids in the blood serum. Feeding rabbits with alloxan diabetes with cholesterol for one month led to earlier and more pronouned atherogenic shifts in the organism than in control animals with the intact beta-cells of the pancreas.

摘要

不同严重程度的四氧嘧啶糖尿病在兔子身上伴有胆固醇和甘油三酯水平升高,同时血清中前β-脂蛋白浓度也逐渐增加。给患四氧嘧啶糖尿病的兔子喂食胆固醇一个月,与胰腺β细胞完好的对照动物相比,会导致机体更早且更明显地出现动脉粥样硬化变化。

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