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[饮食性高血糖在几种脂质代谢紊乱发病机制中的作用]

[Role of alimentary hyperglycemia in the pathogenesis of several disorders of lipid metabolism].

作者信息

Kantardzhian I G, Negovskaia A V

出版信息

Biull Eksp Biol Med. 1976 Mar;81(3):281-3.

PMID:182301
Abstract

Alimentary hyperglycemia in rabbits was found to be accompanied by increase in cholesterol level, as well as in the amount of triglycerides in the blood sera. Progressive increase in the serum concentration of pre-beta lipoproteids (serving as endogenous tryglyceride carrier) has also been demonstrated. A short-term feeding with cholesterol against the background of hyperglycemia in rabbits appeared to result in early marked atherosclerotic changes, as compared to those in control group of normoglycemic animals.

摘要

发现兔的消化性高血糖伴有胆固醇水平升高以及血清中甘油三酯含量增加。还证实了前β脂蛋白(作为内源性甘油三酯载体)的血清浓度逐渐升高。与血糖正常动物的对照组相比,在兔高血糖背景下短期喂食胆固醇似乎会导致早期明显的动脉粥样硬化改变。

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