Minetti L, di Belgiojoso G B, Civati G, Durante A, Scatizzi A, Surian M
Proc Eur Dial Transplant Assoc. 1976;12:210-7.
Five episodes of acute renal failure due to rifampicin (R-ARF) were observed in four patients and the clinical and histological data were compared with the records of 52 episodes reported in the literature. The bulk of data supports the assumption that the by far most frequent renal injury responsible for R-ARF is acute tubular necrosis produced by a vasomotor mechanism. Nevertheless a few data, above all immunohistological findings, suggest the local presence of allergic process. It may be, that the development of an immunological renal lesion is prevented or blunted by the consequences of vasomotor effects.
在4例患者中观察到5例由利福平引起的急性肾衰竭（R-ARF），并将临床和组织学数据与文献报道的52例病例记录进行了比较。大量数据支持这样一种假设，即迄今为止，导致R-ARF的最常见肾损伤是由血管运动机制产生的急性肾小管坏死。然而，一些数据，尤其是免疫组织学结果，提示存在局部过敏反应。血管运动效应的后果可能会阻止或减弱免疫性肾损伤的发展。
