Winchester J F, Apiliga M T, Mackay J M, Kennedy A C
Proc Eur Dial Transplant Assoc. 1976;12:526-33.
An activated charcoal haemoperfusion device containing 300 g acrylic hydrogel coated activated charcoal, was combined with haemodialysis, on six occasions in each of two patients, for a 2-hour portion of a routine 5-hour dialysis schedule. Blood pressure changes with combined treatment were minimised by using a low priming volume dialysis filter. Plasma clearance of both creatinine and urate were increased during the combined haemodialysis-haemoperfusion period. During the two hours of the combined treatment period in one patient creatinine removal amounted to 70% and urate removal to 50% of that obtained during a 5-hour haemodialysis. No significant additional urea or phosphate removal occurred. Changes in middle molecular weight substances with combined treatment were slightly greater than changes occurring with dialysis alone. Haemodialysis alone did not result in a terminal platelet fall, but combined treatment resulted in a terminal 20-30% platelet reduction, despite unchanged platelet counts at the end of the 2-hour haemoperfusion period. This preliminary study suggests that combined haemodialysis-haemoperfusion, is worthy of further scrutiny.
一种含有300克丙烯酸水凝胶包被活性炭的活性炭血液灌流装置，与血液透析联合使用，在两名患者中各进行了6次，在常规5小时透析方案的2小时时段内。通过使用低预充量透析滤器，联合治疗时的血压变化降至最低。在血液透析 - 血液灌流联合期间，肌酐和尿酸的血浆清除率均有所提高。在一名患者的联合治疗两小时期间，肌酐清除量达到5小时血液透析期间的70%，尿酸清除量达到50%。未发生显著的额外尿素或磷酸盐清除。联合治疗时中分子量物质的变化略大于单纯透析时的变化。单纯血液透析未导致末期血小板下降，但联合治疗导致末期血小板减少20 - 30%，尽管在2小时血液灌流期结束时血小板计数未变。这项初步研究表明，血液透析 - 血液灌流联合疗法值得进一步研究。
