Brookings C H, Ramsey J D
Arch Toxicol. 1975 Nov 20;34(3):243-52. doi: 10.1007/BF00353287.
The removal of salicylate by extracorporeal circulation of blood through a column of encapsulated activated charcoal (haemoperfusion) has been studied experimentally in intoxicated dogs (greyhounds). The average time taken to reduce the whole blood salicylate level to one-half of the initial equilibrium level in 30 kg dogs was 2 hrs. A half-life of 3 hrs is predicted for salicylate removal by haemoperfusion in a 70 kg man and this rate of removal is shown to be comparable to that reported for haemodialysis. No unacceptable adverse physiological, biochemical, or haematological effects were found to result from haemoperfusion. The possible use of this technique in the management of severe salicylate poisoning in man is discussed. Haemoperfusion is foreseen as providing a method of rapid removal of salicylate in circumstances where forced diuresis is contra-indicated or inadequate and haemodialysis is not readily available.
通过装有包膜活性炭的柱体进行血液体外循环（血液灌流）来清除水杨酸盐，已在中毒犬（灵缇犬）身上进行了实验研究。在30千克的犬中，将全血水杨酸盐水平降至初始平衡水平的一半所需的平均时间为2小时。预计在一名70千克的男子中，血液灌流清除水杨酸盐的半衰期为3小时，且这种清除率与报道的血液透析清除率相当。未发现血液灌流会导致不可接受的不良生理、生化或血液学影响。讨论了该技术在人类严重水杨酸盐中毒治疗中的可能应用。预计在强制利尿禁忌或不足且血液透析不易获得的情况下，血液灌流可提供一种快速清除水杨酸盐的方法。
