Bacotti A V, Barrett J E
Pharmacol Biochem Behav. 1976 Mar;4(3):299-304. doi: 10.1016/0091-3057(76)90245-8.
Lever pressing of four rats was maintained under a multiple fixed ratio 80, fixed interval 2-min schedule of food presentation. Water was concurrently available from a drinking tube. Overall rates of lever pressing were highest under the fixed ratio schedule and, for three rats, most drinking occurred during the pause preceding responding under the fixed interval schedule. Chlordiazepoxide increased the lower rates of lever pressing maintained under the fixed interval schedule but generally decreased the higher response rates under the fixed ratio schedule. The effects of chlordiazepoxide on schedule-induced licking also depended on the extent to which this response occurred in each schedule component. Typically chlordiazepoxide produced relatively greater increases in the lower levels of licking and either increased less or decreased licking in that component where, under control conditions, this response was more extensive. Chlordiazepoxide also produced overall increases in the total amount of water consumed during the session. When the number of food pellets obtained during the experimental session was given all at one time in the home cage, the amount of water ingested over a period of time equivalent to the session duration was substantially less than that consumed during the experimental session. Chlordiazepoxide did not increase home cage water consumption under this condition.
四只大鼠的杠杆按压行为在多重固定比率80、固定间隔2分钟的食物呈现程序下得以维持。同时，通过饮水管可获取水。在固定比率程序下，杠杆按压的总体速率最高，对于三只大鼠而言，大部分饮水发生在固定间隔程序下反应之前的暂停期间。氯氮卓增加了在固定间隔程序下维持的较低杠杆按压速率，但通常降低了固定比率程序下较高的反应速率。氯氮卓对程序诱导舔舐的影响也取决于该反应在每个程序成分中发生的程度。通常，氯氮卓在较低水平的舔舐中产生相对更大的增加，而在该成分中，在对照条件下该反应更广泛的情况下，要么增加较少要么减少舔舐。氯氮卓还使实验期间消耗的总水量总体增加。当在实验期间获得的食物颗粒数量一次性全部放在饲养笼中时，在相当于实验期间持续时间的一段时间内摄入的水量明显少于实验期间消耗的水量。在这种情况下，氯氮卓不会增加饲养笼中的饮水量。
