谷胱甘肽与新生儿肺部疾病

Glutathione and neonatal lung disease.

作者信息

Reise J A, Taylor G W, Fardy C H, Silverman M

机构信息

Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, UK.

出版信息

Clin Chim Acta. 1997 Sep 8;265(1):113-9. doi: 10.1016/s0009-8981(97)00108-3.

DOI:10.1016/s0009-8981(97)00108-3

PMID:9352134

Abstract

Glutathione (GSH) was measured using HPLC-electrochemical detection in bronchoalveolar lavage fluid from 28 neonates for up to 21 days after birth. GSH levels varied from 0.1-11.2 mumol l-1 (with a geometric mean concentration of 1.3 mumol l-1). GSH in epithelial lining fluid was estimated using the urea dilution method at 15.0 mumol l-1 (range 0.5-196 mumol l-1), which is significantly lower than observed in adult subjects. There was an L shaped relationship between GSH and the two markers of oxygen therapy, oxygen index and FiO2. The lowest GSH levels were associated with the group of infants with the most severe airways problems who required high oxygen.

摘要

出生后长达21天内，采用高效液相色谱-电化学检测法对28例新生儿的支气管肺泡灌洗液中的谷胱甘肽（GSH）进行了检测。GSH水平在0.1 - 11.2 μmol l-1之间（几何平均浓度为1.3 μmol l-1）。采用尿素稀释法估计上皮衬液中的GSH为15.0 μmol l-1（范围为0.5 - 196 μmol l-1），这显著低于在成年受试者中观察到的值。GSH与氧疗的两个指标，即氧指数和吸入氧分数（FiO2）之间呈L形关系。最低的GSH水平与气道问题最严重且需要高浓度氧气的婴儿组相关。