Fruchart C, Salah A, Gray C, Martin E, Stamatoullas A, Bonmarchand G, Lemeland J F, Tilly H
Service d'Hématologie Clinique, Centre Henri Becquerel, Rouen, France.
Eur J Clin Microbiol Infect Dis. 1997 Sep;16(9):681-4. doi: 10.1007/BF01708560.
The intensive use of broad-spectrum antibiotics in the context of prolonged and severe neutropenia has contributed to the emergence of unusual pathogens. Four new cases of severe Lactobacillus infections-three of septicemia and one of pneumonia-are reported. They occurred in patients with acute leukemia who had chemotherapy-induced neutropenia. All patients were treated in the same intensive care unit and received the same antimicrobial prophylaxis which included a total bowel decontamination containing vancomycin. The four patients were treated with a combination of intravenous ceftazidime and vancomycin prior to the development of Lactobacillus infection. Improvement in the condition of all patients was obtained with a treatment including penicillin and concurrent recovery of granulopoiesis.
在长期严重中性粒细胞减少的情况下大量使用广谱抗生素，导致了不常见病原体的出现。本文报告了4例严重乳酸杆菌感染新病例，其中3例为败血症，1例为肺炎。这些病例发生在患有化疗引起的中性粒细胞减少的急性白血病患者中。所有患者均在同一重症监护病房接受治疗，并接受相同的抗菌预防措施，其中包括含有万古霉素的全肠道去污。这4例患者在发生乳酸杆菌感染之前均接受了静脉注射头孢他啶和万古霉素的联合治疗。所有患者通过青霉素治疗及粒细胞生成的同时恢复，病情均得到改善。
