Geber W F, Lefkowitz S S, Hung C Y
Pharmacology. 1976;14(4):322-9. doi: 10.1159/000136611.
The serum titer of interferon produced by polyinosinic:polycytidylic acid (poly I:C) was studied in mice following subcutaneous injections of either morphine alone, naloxone alone, morphine and naloxone together, morphine preceded by naloxone, naloxone preceded by morphine, or a sequence of injections of naloxone, morphine, and naloxone again. Poly I:C injected without the other drugs present served as the control. Both morphine and naloxone produced a significant decrease in the ability of the mice to increase the serum titer of interferon in response to poly I:C. Naloxone appeared to function as an antagonist to morphine when administered following the morphine injection, but not when injected before or simultaneously with the opiate. When naloxone was injected both before and following the morphine injection, results were interpreted to indicate the possibility that naloxone could function as both an agonist and antagonist under this condition.
在小鼠皮下注射单独的吗啡、单独的纳洛酮、吗啡和纳洛酮同时注射、纳洛酮先于吗啡注射、吗啡先于纳洛酮注射或一系列先注射纳洛酮、再注射吗啡、然后再注射纳洛酮之后，研究了聚肌苷酸:聚胞苷酸（聚 I:C）诱导产生的干扰素的血清滴度。在不存在其他药物的情况下注射聚 I:C 作为对照。吗啡和纳洛酮均显著降低了小鼠对聚 I:C 作出反应时提高干扰素血清滴度的能力。当在注射吗啡后给予纳洛酮时，纳洛酮似乎起到了吗啡拮抗剂的作用，但在注射阿片类药物之前或同时注射时则不然。当在注射吗啡之前和之后都注射纳洛酮时，结果被解释为表明在此条件下纳洛酮可能同时起到激动剂和拮抗剂的作用。
