Shiomi Y, Funabiki K, Naito Y, Fujiki N, Tsuji J
Department of Hearing and Speech Science, Faculty of Medicine, Kyoto University, Japan.
Auris Nasus Larynx. 1997 Oct;24(4):351-6. doi: 10.1016/s0385-8146(97)10004-9.
The effect of intravenous injection of lidocaine on hearing thresholds was studied in normal subjects. Continuous and intermittent tones at 1, 4 and 8 kHz were used as stimuli and the threshold change with lidocaine injection was measured using a self-recording audiometer (Békésy audiometer). Both increases and decreases in the threshold were observed. The former occurred more frequently than the latter. In cases of a threshold increase, lidocaine injection exhibited a frequency specific effect; the higher the frequency, the more often the threshold was increased by lidocaine injection. There was no significant difference in threshold changes between continuous and intermittent tones. The present results suggest that lidocaine may act on the inner ear hair cells.
在正常受试者中研究了静脉注射利多卡因对听力阈值的影响。使用1、4和8千赫的连续音和间歇音作为刺激，并使用自记听力计（贝凯西听力计）测量利多卡因注射后的阈值变化。观察到阈值有升高和降低两种情况。前者比后者更频繁出现。在阈值升高的情况下，利多卡因注射表现出频率特异性效应；频率越高，利多卡因注射使阈值升高的情况越频繁。连续音和间歇音之间的阈值变化没有显著差异。目前的结果表明，利多卡因可能作用于内耳毛细胞。
