源自活结核杆菌和死结核杆菌的新型结核分枝杆菌抗原的免疫原性差异
Differential immunogenicity of novel Mycobacterium tuberculosis antigens derived from live and dead bacilli.
作者信息
Amara R R, Satchidanandam V
机构信息
Centre for Genetic Engineering, Indian Institute of Science, Bangalore.
出版信息
Infect Immun. 1997 Nov;65(11):4880-2. doi: 10.1128/iai.65.11.4880-4882.1997.
Abstract
Mouse serum raised against killed antigen preparations of Mycobacterium tuberculosis failed to recognize most of the recombinant antigens of M. tuberculosis that were originally identified by reactivity to tuberculosis (TB) patient sera. Similar results were obtained with serum from guinea pigs immunized with live and killed mycobacteria. Antibodies raised against seven random TB patient serum-reactive antigens detected each of these antigens in the sonicate preparation. The nucleotide sequences of the genes for these seven antigens revealed that all represented hitherto unreported genes of M. tuberculosis. Our results suggest differential presentation to the host immune system of the same antigens derived from live and killed mycobacteria.
摘要
针对结核分枝杆菌灭活抗原制剂产生的小鼠血清无法识别大多数结核分枝杆菌重组抗原，这些重组抗原最初是通过与结核病（TB）患者血清的反应性鉴定出来的。用活的和灭活的分枝杆菌免疫的豚鼠血清也得到了类似结果。针对七种随机的TB患者血清反应性抗原产生的抗体在超声破碎制剂中检测到了每种抗原。这七种抗原的基因核苷酸序列显示，它们均代表迄今未报道的结核分枝杆菌基因。我们的结果表明，活的和灭活的分枝杆菌来源的相同抗原在向宿主免疫系统的呈递上存在差异。
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