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Clin Exp Immunol. 1986 Jan;63(1):105-10.
2
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Vaccination against tuberculosis with nonliving vaccines. I. The problem and its historical background.
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The immunogenicity of killed mycobacteria.灭活分枝杆菌的免疫原性。
Lepr Rev. 1980 Dec;51(4):295-301. doi: 10.5935/0305-7518.19800030.
3
Spontaneous release of a factor with properties of T cell growth factor from a continuous line of primate tumor T cells.从灵长类肿瘤T细胞连续系中自发释放具有T细胞生长因子特性的一种因子。
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Infection with Mycobacterium avium-intracellulare and the protective effects of Bacille Calmette-Guérin.鸟分枝杆菌-胞内分枝杆菌感染及卡介苗的保护作用。
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Inhibition of the proliferative response of peripheral blood lymphocytes to mycobacterial or fungal antigens by co-stimulation with antigens from various mycobacterial species.通过与来自各种分枝杆菌属的抗原共同刺激来抑制外周血淋巴细胞对分枝杆菌或真菌抗原的增殖反应。
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6
Skin-test sensitisation by tubercle bacilli and by other mycobacteria in Ethiopian school-children.埃塞俄比亚学童中结核杆菌及其他分枝杆菌引起的皮肤试验致敏反应。
Tubercle. 1984 Dec;65(4):285-93. doi: 10.1016/0041-3879(84)90038-2.
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Antigen-specific human T-lymphocyte clones. Genetic restriction of influenza virus-specific responses to HLA-D region genes.
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Long-term results of BCG vaccination in the southern United States.美国南部卡介苗接种的长期结果。
Am Rev Respir Dis. 1966 Feb;93(2):171-83. doi: 10.1164/arrd.1966.93.2.171.
9
B.C.G. vaccination of children against leprosy in Uganda: results at end of second follow-up.乌干达儿童接种卡介苗预防麻风病：第二次随访结束时的结果
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I-A restricted activation by T cell lines of anti-tuberculosis activity in murine macrophages.I-A限制小鼠巨噬细胞中抗结核活性的T细胞系激活。
Clin Exp Immunol. 1985 Feb;59(2):414-20.

正常供体的超声处理刺激的T细胞系对活结核分枝杆菌及常见抗原的反应性。

Responsiveness to live M. tuberculosis, and common antigens, of sonicate-stimulated T cell lines from normal donors.

作者信息

Rook G A, Steele J, Barnass S, Mace J, Stanford J L

出版信息

Clin Exp Immunol. 1986 Jan;63(1):105-10.

PMID:3082544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1577333/
Abstract

Live mycobacteria are more efficient vaccines against mycobacterial disease than killed ones. A possible explanation is the existence of important protective antigens released by live bacilli, which are not present in any significant quantity in dead ones. Conversely, internal mycobacterial antigens may be irrelevant to protection if not released by live bacilli. We show here, using T cell lines derived by limiting dilution from the peripheral blood of normal donors stimulated with sonicated BCG, that a variable percentage of sonicate responsive T cells is unable to respond to live M. tuberculosis. The possibility that such lines have an immunopathological, rather than protective role, is discussed.

摘要

活的分枝杆菌作为抗分枝杆菌病的疫苗比死的分枝杆菌更有效。一种可能的解释是活杆菌释放出重要的保护性抗原，而死杆菌中不存在大量此类抗原。相反，如果内部分枝杆菌抗原不是由活杆菌释放的，那么它们可能与保护作用无关。我们在此表明，使用从用超声处理的卡介苗刺激的正常供体外周血中通过有限稀释获得的T细胞系，一定比例的对超声处理物有反应的T细胞无法对活的结核分枝杆菌作出反应。本文讨论了此类细胞系具有免疫病理作用而非保护作用的可能性。