正常供体的超声处理刺激的T细胞系对活结核分枝杆菌及常见抗原的反应性。
Responsiveness to live M. tuberculosis, and common antigens, of sonicate-stimulated T cell lines from normal donors.
作者信息
Rook G A, Steele J, Barnass S, Mace J, Stanford J L
出版信息
Clin Exp Immunol. 1986 Jan;63(1):105-10.
Abstract
Live mycobacteria are more efficient vaccines against mycobacterial disease than killed ones. A possible explanation is the existence of important protective antigens released by live bacilli, which are not present in any significant quantity in dead ones. Conversely, internal mycobacterial antigens may be irrelevant to protection if not released by live bacilli. We show here, using T cell lines derived by limiting dilution from the peripheral blood of normal donors stimulated with sonicated BCG, that a variable percentage of sonicate responsive T cells is unable to respond to live M. tuberculosis. The possibility that such lines have an immunopathological, rather than protective role, is discussed.
摘要
活的分枝杆菌作为抗分枝杆菌病的疫苗比死的分枝杆菌更有效。一种可能的解释是活杆菌释放出重要的保护性抗原，而死杆菌中不存在大量此类抗原。相反，如果内部分枝杆菌抗原不是由活杆菌释放的，那么它们可能与保护作用无关。我们在此表明，使用从用超声处理的卡介苗刺激的正常供体外周血中通过有限稀释获得的T细胞系，一定比例的对超声处理物有反应的T细胞无法对活的结核分枝杆菌作出反应。本文讨论了此类细胞系具有免疫病理作用而非保护作用的可能性。
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