Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843-2128, USA.
Protein Sci. 2011 May;20(5):827-33. doi: 10.1002/pro.607. Epub 2011 Mar 30.
In eukaryotes, calcium-binding proteins play a pivotal role in diverse cellular processes, and recent findings suggest similar roles for bacterial proteins at different stages in their life cycle. Here, we report the crystal structure of calcium dodecin, Rv0379, from Mycobacterium tuberculosis with a dodecameric oligomeric assembly and a unique calcium-binding motif. Structure and sequence analysis were used to identify orthologs of Rv0379 with different ligand-binding specificity.
在真核生物中，钙结合蛋白在多种细胞过程中发挥着关键作用，最近的研究结果表明，细菌蛋白在其生命周期的不同阶段也发挥着类似的作用。在这里，我们报告了来自结核分枝杆菌的钙十二聚体 Rv0379 的晶体结构，其具有十二聚体寡聚组装和独特的钙结合基序。结构和序列分析用于鉴定具有不同配体结合特异性的 Rv0379 的同源物。
