Schulte P A, Hunter D, Rothman N
National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA.
IARC Sci Publ. 1997(142):313-8.
The use of biomarkers in epidemiological research may raise ethical and social issues. These issues stem from the belief that research participants have 'rights' to appropriate information before, during and after studies so that they can make informed decisions. Ethical issues can arise during protocol development, obtaining participation, and in the interpretation and notification of text and study results. Additionally, there are ethical considerations concerning the use of biological specimens collected and stored for one purpose and subsequently used for other research purposes. A major ethical issue is the maintenance of participants' privacy and the confidentiality of their test and study results. Ethics committees need to be well-informed about the scope, limitations and expectations of biomarker research in order to be able to respond to social and scientific developments in the use of biomarkers.
生物标志物在流行病学研究中的应用可能引发伦理和社会问题。这些问题源于这样一种观念，即研究参与者在研究前、研究期间和研究后有权获得适当的信息，以便他们能够做出明智的决定。在方案制定、获取参与以及文本和研究结果的解释与告知过程中，都可能出现伦理问题。此外，对于为某一目的收集和存储的生物标本随后用于其他研究目的，也存在伦理考量。一个主要的伦理问题是维护参与者的隐私以及他们检测和研究结果的保密性。伦理委员会需要充分了解生物标志物研究的范围、局限性和期望，以便能够应对生物标志物使用方面的社会和科学发展。
