Maeshima A, Murakami H, Sadakata H, Saitoh T, Matsushima T, Tamura J, Karasawa M, Naruse T
Third Department of Internal Medicine, Gunma University School of Medicine, Japan.
J Med. 1997;28(3-4):265-72.
We present the findings on a 27-year-old male with eosinophilic gastro-enterocolitis accompanied with acute pancreatitis. Acute pancreatitis may be induced by pancreatic duct obstruction caused by marked swelling of the papillary region of the duodenum due to eosinophil infiltration. After prednisolone treatment, clinical manifestations rapidly improved; the serum amylase decreased and the peripheral eosinophilia was recovered. The serum interleukin-5 (IL-5) level was high at diagnosis and decreased by prednisolone therapy; however, IL-5 was detected by enzyme immunoassay even during clinical remission. These results indicate that eosinophilia is mediated by IL-5, and detectable levels of IL-5 indicate the possibility of relapse.
我们报告了一名27岁男性嗜酸性胃肠结肠炎伴急性胰腺炎的病例。急性胰腺炎可能是由于十二指肠乳头区域因嗜酸性粒细胞浸润而明显肿胀，导致胰管梗阻所致。泼尼松龙治疗后，临床表现迅速改善；血清淀粉酶降低，外周嗜酸性粒细胞增多恢复正常。诊断时血清白细胞介素-5（IL-5）水平较高，泼尼松龙治疗后降低；然而，即使在临床缓解期，酶免疫测定仍可检测到IL-5。这些结果表明，嗜酸性粒细胞增多是由IL-5介导的，可检测到的IL-5水平表明有复发的可能性。
