Jouanguy E, Altare F, Lamhamedi-Cherradi S, Casanova J L
INSERM U429, Hôpital Necker-Enfants Malades, Paris, France.
J Interferon Cytokine Res. 1997 Oct;17(10):583-7. doi: 10.1089/jir.1997.17.583.
Human interferon-gamma receptor 1 (IFNGR-1) deficiency is a newly identified autosomal recessive inherited immune disorder. Children with IFNGR-1 deficiency exhibit a severe, profound and selective susceptibility to weakly virulent mycobacteria, such as bacillus Calmette-Guerin (BCG) vaccine or environmental nontuberculous mycobacteria (NTM). This review compares the infections found in IFNGR-1-deficient children to those in IFN-gamma-deficient or IFNGR-1-deficient mice.
人类干扰素-γ受体1（IFNGR-1）缺乏症是一种新发现的常染色体隐性遗传性免疫疾病。IFNGR-1缺乏症患儿对弱毒力分枝杆菌，如卡介苗（BCG）疫苗或环境非结核分枝杆菌（NTM）表现出严重、深度和选择性易感性。本综述比较了IFNGR-1缺乏症患儿与IFN-γ缺乏或IFNGR-1缺乏小鼠的感染情况。
