Zerbe Christa S, Holland Steven M
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Clin Infect Dis. 2005 Aug 15;41(4):e38-41. doi: 10.1086/432120. Epub 2005 Jul 15.
Mutations in the interferon (IFN)-gamma receptor predispose to infection with bacille Calmette-Guérin, nontuberculous mycobacteria, and Salmonella organisms. We identified a patient with recurrent disseminated Histoplasma capsulatum osteomyelitis who had an autosomal dominant form of IFN-gamma receptor 1 deficiency (i.e., a 4-bp deletion at or near base 818). IFN-gamma-mediated immunity is important in the control of histoplasmosis.
干扰素（IFN）-γ受体的突变易使人感染卡介苗、非结核分枝杆菌和沙门氏菌。我们鉴定出一名患有复发性播散性荚膜组织胞浆菌骨髓炎的患者，其存在常染色体显性形式的IFN-γ受体1缺陷（即818位碱基或其附近有一个4碱基缺失）。IFN-γ介导的免疫在组织胞浆菌病的控制中很重要。
