Zorich N L, Biedermann D, Riccardi K A, Bishop L J, Filloon T G
Department of Medical Affairs, OLEAN, Procter & Gamble Company, Cincinnati, Ohio 45224, USA.
Regul Toxicol Pharmacol. 1997 Oct;26(2):200-9. doi: 10.1006/rtph.1997.1164.
Olestra is a zero-calorie fat substitute that is neither digested nor absorbed. A randomized, double-blind, placebo-controlled, within-subject, crossover rechallenge study was conducted to compare the occurrence of gastrointestinal symptoms after ingestion of chips made with Olean brand of olestra or conventional triglycerides in subjects who had previously experienced gastrointestinal symptoms they attributed to consuming Olean. A total of 57 male or female subjects received 2 oz of Olean potato chips or triglyceride potato chips at each of four weekly site visits. The occurrence of gastrointestinal effects after product consumption was noted in follow-up telephone interviews 3 to 5 days after each visit. There was no significant difference in the frequency of any gastrointestinal symptoms (abdominal cramping, diarrhea, loose stools) following consumption of Olean chips or triglyceride chips, and the severity of diarrhea, loose stools, and abdominal cramping was similar. We conclude that consumption of a 2-oz serving of Olean chips is no more likely to result in reports of gastrointestinal symptoms than consumption of triglyceride snacks as a part of the usual diet, even in individuals who have claimed intolerance to Olean. The data suggest that subjects who previously experienced symptoms that they attributed to consuming products made with Olean may have mistakenly attributed their symptoms to these products.
奥利斯特拉是一种零热量的脂肪替代品，既不被消化也不被吸收。进行了一项随机、双盲、安慰剂对照、受试者自身交叉再激发研究，以比较在曾经历过他们认为是食用含奥利斯特拉的奥力安品牌产品所致胃肠道症状的受试者中，摄入用奥力安牌奥利斯特拉或传统甘油三酯制成的薯片后胃肠道症状的发生情况。共有57名男性或女性受试者在每周一次的四个研究点访视中，每次都接受2盎司的奥力安薯片或甘油三酯薯片。在每次访视后3至5天的随访电话访谈中记录食用产品后胃肠道效应的发生情况。食用奥力安薯片或甘油三酯薯片后，任何胃肠道症状（腹部绞痛、腹泻、稀便）的发生频率均无显著差异，腹泻、稀便和腹部绞痛的严重程度也相似。我们得出结论，作为日常饮食的一部分，食用2盎司的奥力安薯片与食用甘油三酯零食相比，引发胃肠道症状报告的可能性并不更高，即使是那些声称对奥力安不耐受的个体。数据表明，那些曾经历过他们认为是食用含奥利斯特拉产品所致症状的受试者，可能错误地将其症状归因于这些产品。
