对镉诱导的药物作用改变产生耐受性的发展。

Tolerance development to cadmium-induced alteration of drug action.

作者信息

Roberts S A, Miya T S, Schnell R C

出版信息

Res Commun Chem Pathol Pharmacol. 1976 May;14(1):197-200.

Abstract

Cadmium administration potentiates the duration of hexobarbital-induced hypnosis and inhibits the rate of hepatic microsomal metabolism of this drug in the male rat. The threshold dose of cadmium required to produce these alterations in drug action is 0.84 mg Ck/kg. If subthreshold doses of cadmium (0.21 or 0.42 mg Cd/kg) are administered prior to the 0.84 mg Cd/kg dose, the cadmium-induced alterations in drug action are no longer observed.

摘要

给雄性大鼠施用镉会延长己巴比妥诱导的催眠持续时间，并抑制该药物在肝脏微粒体中的代谢速率。产生这些药物作用改变所需的镉阈值剂量为0.84毫克镉/千克。如果在施用0.84毫克镉/千克剂量之前先施用阈下剂量的镉（0.21或0.42毫克镉/千克），则不再观察到镉诱导的药物作用改变。