镉诱导的大鼠药物作用改变中的性别差异。

Sex-related differences in cadmium-induced alteration of drug action in the rat.

作者信息

Schnell R C, Pence D H, Prosser T D, Miya T

出版信息

Toxicology. 1976 Nov-Dec;6(3):277-9. doi: 10.1016/0300-483x(76)90030-5.

Abstract

3 days after pretreatment of rats of both sexes with cadmium (2 mg/kg, 1.p.) the duration of hypnosis induced by hexobarbital (75 mg/kg, 1.p.) was potentiated in males but not females. Likewise similar treatment with cadmium leads to significant inhibition of the metabolism of hexobarbital by hepatic microsomal enzymes obtained from male but not female animals. These data suggest that there is a sex-related difference in the ability of cadmium to alter drug action in rats.

摘要

用镉（2毫克/千克，腹腔注射）对雌雄大鼠进行预处理3天后，雄性大鼠由己巴比妥（75毫克/千克，腹腔注射）诱导的催眠持续时间增强，而雌性大鼠则没有。同样，用镉进行类似处理会导致从雄性而非雌性动物获得的肝微粒体酶对己巴比妥代谢产生显著抑制。这些数据表明，镉改变大鼠药物作用的能力存在性别差异。