Sex-related differences in doxapram-induced alteration of drug action in the rat.
作者信息
Ishikawa M, Ozaki M, Takayanagi Y, Sasaki K
机构信息
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
出版信息
Res Commun Chem Pathol Pharmacol. 1989 Sep;65(3):397-400.
PMID:2813960
Abstract
Pretreatment of rats with doxapram (20 mg/kg, i.p.) potentiates the duration of hexobarbital hypnosis and inhibits the rate of hepatic hexobarbital metabolism in female rats but not male rats. These data show that there is a sex-related difference in the ability of doxapram to alter both the drug response and hepatic drug metabolism in rats.
摘要
Zotero 插件