Talwar D, Ha T K, Scott H R, Cooney J, Fell G S, O'Reilly D S, Lean M E, McMillan D C
Department of Human Nutrition, Royal Infirmary, Glasgow, United Kingdom.
Am J Clin Nutr. 1997 Nov;66(5):1283-5. doi: 10.1093/ajcn/66.5.1283.
This study examined the effect of an inflammatory response on measures of antioxidant status in patients with non-small cell lung cancer (NSCLC). In healthy, control subjects (n = 13) and NSCLC patients (n = 22) fasting concentrations of albumin, C-reactive protein, cholesterol, and the antioxidants alpha-tocopherol, retinol, lutein, lycopene, and alpha- and beta-carotene were measured. The two groups were similar in terms of age, sex, and body mass index. However, the cancer group had an inflammatory response as evidenced by significantly increased C-reactive protein concentrations. Concentrations of all the measured antioxidants of the NSCLC group were significantly lower than those of the control group (P < 0.01). The lowest concentrations were those of the carotenoids lycopene and alpha- and beta-carotene. In the cancer group there were significant negative correlations between concentrations of C-reactive protein and retinol (r = -0.682, P < 0.01), alpha-tocopherol (r = -0.464, P < 0.05), and lutein (r = -0.599, P < 0.01). The results of this study have implications for the interpretation of circulating antioxidant concentrations in patients with NSCLC.
本研究调查了炎症反应对非小细胞肺癌（NSCLC）患者抗氧化状态指标的影响。测量了健康对照受试者（n = 13）和NSCLC患者（n = 22）空腹时白蛋白、C反应蛋白、胆固醇以及抗氧化剂α-生育酚、视黄醇、叶黄素、番茄红素、α-胡萝卜素和β-胡萝卜素的浓度。两组在年龄、性别和体重指数方面相似。然而，癌症组存在炎症反应，C反应蛋白浓度显著升高证明了这一点。NSCLC组所有测量的抗氧化剂浓度均显著低于对照组（P < 0.01）。最低浓度的是类胡萝卜素番茄红素、α-胡萝卜素和β-胡萝卜素。在癌症组中，C反应蛋白浓度与视黄醇（r = -0.682，P < 0.01）、α-生育酚（r = -0.464，P < 0.05）和叶黄素（r = -0.599，P < 0.01）之间存在显著的负相关。本研究结果对解释NSCLC患者循环抗氧化剂浓度具有启示意义。
