哮喘患者单次服用未包衣控释茶碱片后血清茶碱浓度的个体间变异性。

Intersubject variability of serum theophylline concentration after single dose of uncoated controlled release theophylline tablet administration in asthmatic patients.

作者信息

Raj N S, Guleria R, Misra A, Pande J N

机构信息

Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Indian J Chest Dis Allied Sci. 1997 Jul-Sep;39(3):143-7.

PMID:9357147

Abstract

Various reports indicate significant intersubject variation in the rate of absorption of controlled release theophylline products that are commercially available. Serum theophylline concentration was estimated in 17 asthma patients treated with controlled release theophylline tablet (mean dose: 5.6 +/- 0.6 mg/kg, mean body wt: 49.82 +/- 9.05 kg). The mean maximal concentration (Cmax) of 5.57 +/- 1.65 micrograms/ml occurred at mean time of maximal concentration (Tmax) of 3.3 +/- 1.36 (mean +/- SD) hours. Mean minimal concentration (Cmin) was 3.164 +/- 1.1 micrograms/ml (mean +/- SD) at mean time of minimal concentration (Tmin) of 5.77 +/- 1.77 (mean +/- SD) hours. The mean percent fluctuation was 112.95 +/- 183.45 (mean +/- SD) but in 4 out of 17 patients, percent fluctuation was 107.29 to 823.10. Therefore, 23.5% patients treated with controlled release theophylline tablet had wide fluctuations in serum theophylline concentration.

摘要

各种报告表明，市售的控释茶碱产品在吸收速率方面存在显著的个体间差异。对17例接受控释茶碱片治疗的哮喘患者（平均剂量：5.6±0.6mg/kg，平均体重：49.82±9.05kg）的血清茶碱浓度进行了估算。平均最大浓度（Cmax）为5.57±1.65μg/ml，出现在平均达峰时间（Tmax）3.3±1.36（平均±标准差）小时。平均最低浓度（Cmin）为3.164±1.1μg/ml（平均±标准差），出现在平均谷浓度时间（Tmin）5.77±1.77（平均±标准差）小时。平均波动百分比为112.95±183.45（平均±标准差），但在17例患者中有4例的波动百分比为107.29至823.10。因此，23.5%接受控释茶碱片治疗的患者血清茶碱浓度波动较大。