Goldberg D J, Whitworth J
Skin Laser Center of NJ, Westwood 07675, USA.
Dermatol Surg. 1997 Oct;23(10):903-6; discussion 906-7. doi: 10.1111/j.1524-4725.1997.tb00744.x.
Recent studies have shown that char-free pulsed carbon dioxide lasers are useful in the treatment of rhytids. Other infrared lasers have also been observed to induce changes in the skin.
In this pilot study, we evaluated the rhytid resurfacing capability of the Q-switched neodymium:yttrium-aluminum-garden (QS Nd:YAG) laser at 1064 nm as compared with char-free carbon dioxide lasers at 10,600 nm.
Three lasers were used in the study: The QS Nd:YAG laser, the SilkTouch carbon dioxide laser, and the UltraPulse carbon dioxide laser. Eleven subjects were treated in either the periorbital or perioral region with the QS Nd:YAG laser on one side of the face, and both of the char-free pulsed carbon dioxide lasers on the other side. The subjects were evaluated at posttreatment days 7, 30, 60, and 90 for improvement of rhytids, healing, pigmentary changes, and erythema.
All 11 patients treated with the char-free carbon dioxide lasers improved. Nine of 11 patients treated with the QS Nd:YAG laser were improved. Healing (complete reepithelialization) was noted to occur 3-6 days earlier in sites treated with the QS Nd:YAG than in sites treated with char-free carbon dioxide lasers. Pigmentary changes were not observed in any treatment site. Erythema was observed at 1 month after treatment in all areas treated with the char-free carbon dioxide lasers, but only three patients treated with the QS Nd:YAG exhibited erythema. These were the same three QS Nd:YAG-treated patients whose clinical improvement was comparable with that of the char-free carbon dioxide lasers.
The Q-switched Nd:YAG laser may play a role in the treatment of rhytids.
近期研究表明，无炭化脉冲二氧化碳激光在皱纹治疗中有效。其他红外激光也被观察到可引起皮肤变化。
在这项初步研究中，我们评估了1064纳米调Q钕：钇铝石榴石（QS Nd:YAG）激光与10600纳米无炭化二氧化碳激光相比的皱纹磨皮能力。
研究中使用了三种激光：QS Nd:YAG激光、SilkTouch二氧化碳激光和UltraPulse二氧化碳激光。11名受试者在面部一侧的眶周或口周区域用QS Nd:YAG激光治疗，另一侧用两种无炭化脉冲二氧化碳激光治疗。在治疗后第7、30、60和90天对受试者进行评估，观察皱纹改善情况、愈合情况、色素沉着变化和红斑情况。
所有11例接受无炭化二氧化碳激光治疗的患者均有改善。11例接受QS Nd:YAG激光治疗的患者中有9例有改善。观察到用QS Nd:YAG激光治疗的部位比用无炭化二氧化碳激光治疗的部位提前3 - 6天实现愈合（完全重新上皮化）。在任何治疗部位均未观察到色素沉着变化。用无炭化二氧化碳激光治疗的所有区域在治疗后1个月均出现红斑，但只有3例接受QS Nd:YAG激光治疗的患者出现红斑。这3例接受QS Nd:YAG激光治疗的患者的临床改善情况与接受无炭化二氧化碳激光治疗的患者相当。
调Q Nd:YAG激光在皱纹治疗中可能发挥作用。
