Yongqian Cao, Li Lin, Jianhai Bi, Ran Huo, Li Guo, Hao Wei, Xining Wang, Shigang Xie, Yibing Wang
Department of Burns and Plastic Surgery, Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China.
Lasers Med Sci. 2017 May;32(4):765-769. doi: 10.1007/s10103-017-2161-6. Epub 2017 Mar 15.
We aimed to investigate the efficacy and safety of using the 1064-nm Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser (QSNYL) for skin rejuvenation in patients with Nevus of Ota. A retrospective, randomized, split-faced, clinical study was conducted. Twenty-nine patients with unilateral moderate to severe Nevus of Ota were enrolled. The participants completed 3-13 sessions of QSNYL treatments 3-6 months apart. Two independent physicians compared the treated and untreated sides of the face to evaluate the clearance of Nevus of Ota, the wrinkle severity rating scale (WSRS), the global aesthetic improvement scale (GAIS), and adverse event reporting. Patients' satisfaction levels were also considered. Of the 29 patients, 28 (96.6%) achieved nearly complete pigmentation clearance. After an average of 7.76 ± 2.99 sessions, statistically significant improvement in wrinkles and skin texture were observed, compared with the untreated side. The degree of skin rejuvenation was positively correlated with the number of treatment sessions. No clinically adverse effects were observed. Repeated QSNYL treatments not only remove the pigment in Nevus of Ota effectively and safely but also improve facial rejuvenation.
我们旨在研究使用1064纳米调Q掺钕钇铝石榴石（Nd:YAG）激光（QSNYL）对太田痣患者进行皮肤年轻化治疗的疗效和安全性。进行了一项回顾性、随机、半脸对照的临床研究。纳入了29例单侧中度至重度太田痣患者。参与者每隔3至6个月完成3至13次QSNYL治疗。两名独立的医生比较面部治疗侧和未治疗侧，以评估太田痣的清除情况、皱纹严重程度评分量表（WSRS）、整体美学改善量表（GAIS）以及不良事件报告。还考虑了患者的满意度水平。29例患者中，28例（96.6%）实现了几乎完全的色素沉着清除。平均经过7.76±2.99次治疗后，与未治疗侧相比，皱纹和皮肤质地有统计学意义的改善。皮肤年轻化程度与治疗次数呈正相关。未观察到临床不良反应。重复进行QSNYL治疗不仅能有效、安全地去除太田痣中的色素，还能改善面部年轻化。
