胃底扩张对人体胃酸分泌的影响。
Effect of fundic distension on gastric acid secretion in man.
作者信息
Grötzinger U, Bergegårdh S, Olbe L
出版信息
Gut. 1977 Feb;18(2):105-10. doi: 10.1136/gut.18.2.105.
The effect of distension of the fundus and body of the stomach on gastric acid secretion was studied in 26 patients with duodenal ulcer and six healthy subjects. Graded distension produced by inflating a rubber balloon to volumes of 150, 300, and 600 ml resulted in significant sequential increments of acid output. The secretory response outlasted stimulation by at least one hour. In both groups of subjects, the highest acid output obtainable with fundic distension amounted to just above 50% of the maximum secretory response evoked by intravenous infusion of pentagastrin. A significant correlation was found between the peak secretory rates observed during fundic distension and after pentagastrin stimulation. It is concluded that distension of the oxyntic gland area in man is a potent stimulus for gastric secretion of acid and that patients with duodenal ulcer are no more sensitive to this stimulus than healthy subjects.
对26例十二指肠溃疡患者和6名健康受试者研究了胃底和胃体扩张对胃酸分泌的影响。通过向橡胶气球充气至150、300和600毫升的体积进行分级扩张，导致酸分泌量显著依次增加。分泌反应持续至少一小时，超过刺激时间。在两组受试者中，胃底扩张可获得的最高酸分泌量仅略高于静脉输注五肽胃泌素引起的最大分泌反应的50%。发现胃底扩张期间观察到的峰值分泌率与五肽胃泌素刺激后之间存在显著相关性。得出的结论是，人胃泌酸腺区的扩张是胃酸分泌的有效刺激，十二指肠溃疡患者对这种刺激的敏感性并不比健康受试者更高。
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