Arnesen H, Akesson I, Strömme S B, Refsum H E
Scand J Haematol. 1976 Apr;16(4):279-84. doi: 10.1111/j.1600-0609.1976.tb01151.x.
The presence of FDP in the urine, known to be a sensitive indicator of various kidney disorders, was studied in 14 well-trained men participating in a 70-km cross-country ski race. None of the urine samples contained FDP on the day before the race. Immediately after the race, 4 samples contained FDP. High molecular weight FDP were found in 2 of them, whereas 2 others contained low molecular weight products only. 2 days after the race, 1 of these subjects still had FDP in the urine. In addition, 2 newly FDP positives were observed. Serum FDP were slightly elevated in 2 subjects before the race, and in another subject immediately after the race. The presence of urinary FDP did not correlate either with urinary albumin or uromucoid, or with serum FDP. A drop in plasma fibrinogen immediately after the race was noted in all subjects. It is suggested that the present observations may reflect a transient hyperproteolysis (coagulation and fibrinolysis) in the glomerular circulation, including fibrin formation and dissolution, associated with a transient damage of glomerular capillaries.
尿中纤维蛋白降解产物（FDP）的存在是各种肾脏疾病的敏感指标，本研究检测了14名训练有素的男性在参加70公里越野滑雪比赛后的尿FDP情况。比赛前一天，所有尿样均未检测到FDP。比赛结束后即刻，4份尿样检测到FDP。其中2份含有高分子量FDP，另外2份仅含有低分子量产物。比赛后2天，这些受试者中有1人尿中仍有FDP。此外，还观察到2例新的FDP阳性。比赛前2名受试者血清FDP略有升高，比赛结束后即刻另1名受试者血清FDP升高。尿FDP的存在与尿白蛋白、尿黏蛋白或血清FDP均无相关性。所有受试者在比赛结束后即刻血浆纤维蛋白原均下降。提示本观察结果可能反映了肾小球循环中短暂的高蛋白水解（凝血和纤溶），包括纤维蛋白形成和溶解，伴有肾小球毛细血管的短暂损伤。
