Hausen B M, Knight T E, Milbrodt M
Dermatology Center, Buxtehude, Germany.
Am J Contact Dermat. 1997 Dec;8(4):225-8.
The allergenic properties of milo wood have not been known before now.
We investigated the wood and elucidated the structure of its main sensitizer.
A bowl turner suffered from allergic contact dermatitis over years. Wood shavings were extracted, and the constituents were isolated, purified, and identified. The sensitizing capacity of the main compound was determined experimentally in guinea pigs.
Initially, patch tests with sawdust suspensions and the isolated main constituent were positive. During the course of the study, however, the patient developed tolerance. The main component of milo wood was identified as a new mansonone: 7-hydroxy-2,3,5,6-tetrahydro-3,6, 9-trimethylnaphtho [1,8 bc] pyran-4,8-dione. In the sensitizing experiments, it showed to be a moderate sensitizer.
Extensive and long-lasting exposure to certain sensitizers may cause the phenomenon of hardening as has been shown in the wood working industry.
此前尚不清楚米洛木的致敏特性。
我们对该木材进行了研究，并阐明了其主要致敏原的结构。
一名碗碟车工多年来患有过敏性接触性皮炎。提取木屑，分离、纯化并鉴定其成分。通过在豚鼠身上进行实验来确定主要化合物的致敏能力。
最初，用木屑悬浮液和分离出的主要成分进行斑贴试验呈阳性。然而，在研究过程中，患者产生了耐受性。米洛木的主要成分被鉴定为一种新的曼森酮：7-羟基-2,3,5,6-四氢-3,6,9-三甲基萘并[1,8 - bc]吡喃-4,8-二酮。在致敏实验中，它显示为一种中度致敏原。
如木材加工行业所表明的那样，长期大量接触某些致敏原可能会导致耐受现象。
