Dietrichson O, From A, Christoffersen P, Juhl E
Scand J Rheumatol. 1976;5(2):65-9. doi: 10.3109/03009747609099892.
Oxphenisatin is known to induce liver damage and is suspected to cause or perpetuate chronic liver disease. In order to evaluate the hepatotoxic effect of long-term therapy with oxyphenisatin 26 consecutive patients with rheumatoid arthritis were investigated for the presence of liver disease. In all cases, liver biopsy, biochemical liver function tests and determination of Hepatitis-B antigen were performed. Ten patients showed no pathological changes in the liver biopsy and a further 2 had only non-specific changes. Seven patients had fatty liver, 5 passive congestion, one haemosiderosis and only one had cirrhosis of the liver. No correlation was found between the activity of rheumatoid arthritis, and duration of the disease, the drug therapy given, and the liver damage.
已知酚酞会引起肝损伤，并被怀疑会引发或使慢性肝病恶化。为评估长期使用酚酞治疗的肝毒性作用，对26例类风湿性关节炎患者进行了连续研究，以检查是否存在肝脏疾病。所有病例均进行了肝活检、生化肝功能检查及乙肝抗原测定。10例患者肝活检未显示病理变化，另有2例仅有非特异性变化。7例有脂肪肝，5例有被动性充血，1例有含铁血黄素沉着症，仅1例有肝硬化。未发现类风湿性关节炎的活动程度、病程、所给予的药物治疗与肝损伤之间存在关联。
