Similä S, Kouvalainen K, Keinänen S
Scand J Rheumatol. 1976;5(2):81-3. doi: 10.3109/03009747609099895.
The capacity of ibuprofen to reduce fever in children was compared with that of aspirin, paracetamol, aminophenazone and indomethacin. The series of cases studied consisted of 79 patients in the age range 3 months to 13 years and with a rectal temperature above 38.5 degrees C. Temperatures were recorded at 15 and 30 minutes, and 1,2,4 and 6 hours after challenge with the drug. The antipyretic effect of ibuprofen with a dose of 6 mg/kg was optimal and twice that of aspirin or paracetamol and similar to that of aminophenazone. The antipyretic effect of indomethacin was about 12 times that of ibuprofen. This ratio is almost the same as what is said to occur between the antirheumatic effects between these drugs. Ibuprofen with a dose of 6 mg/kg would thus appear to be a useful antipyretic drug when both antipyretic and antirheumatic effects are needed.
将布洛芬与阿司匹林、对乙酰氨基酚、氨基苯乙酮和吲哚美辛降低儿童体温的能力进行了比较。所研究的病例系列包括79名年龄在3个月至13岁之间、直肠温度高于38.5摄氏度的患者。在用药激发后15分钟、30分钟以及1、2、4和6小时记录体温。剂量为6mg/kg的布洛芬的退热效果最佳，是阿司匹林或对乙酰氨基酚的两倍，与氨基苯乙酮的效果相似。吲哚美辛的退热效果约为布洛芬的12倍。该比例与这些药物之间抗风湿作用的比例几乎相同。因此，当需要同时具备退热和抗风湿作用时，剂量为6mg/kg的布洛芬似乎是一种有用的退热药。
