Kandoth P W, Joshi M K, Joshi V R, Satoskar R S
J Int Med Res. 1984;12(5):292-7. doi: 10.1177/030006058401200505.
The antipyretic activity of ibuprofen and aspirin was compared in sixteen children with pyrexia due to upper respiratory tract infection and in twelve with fever due to other causes. All 28 children received ibuprofen (7 mg/kg of body-weight) and aspirin (15 mg/kg of body-weight) in a single dose on 2 consecutive days in a crossover manner. Rectal temperature was recorded prior to and at regular intervals up to 8 hours after drug administration. Analysis of the results indicate that ibuprofen and aspirin effectively lower temperature and the two drugs are comparable in their antipyretic activity. In conclusion, significant antipyretic activity, good tolerance profile and availability in syrup form make ibuprofen a useful substitute for aspirin in children with fever.
对16名因上呼吸道感染发热的儿童和12名因其他原因发热的儿童，比较了布洛芬和阿司匹林的退热活性。28名儿童均以交叉方式，连续2天每日单次服用布洛芬（7毫克/千克体重）和阿司匹林（15毫克/千克体重）。给药前及给药后直至8小时期间，每隔一定时间记录直肠温度。结果分析表明，布洛芬和阿司匹林均能有效降低体温，两种药物的退热活性相当。总之，显著的退热活性、良好的耐受性以及糖浆剂型，使布洛芬成为发热儿童替代阿司匹林的有用药物。
