Zeitlhofer J, Gruber G, Anderer P, Asenbaum S, Schimicek P, Saletu B
University Clinic of Neurology, Wien, Austria.
J Sleep Res. 1997 Sep;6(3):149-55. doi: 10.1046/j.1365-2869.1997.00046.x.
The application of an automatic sleep spindle detection procedure allowed the documentation of the topographic distribution of spindle characteristics, such as number, amplitude, frequency and duration, as a function of sleep depth and of recording time. Multichannel all-night EEG recordings were performed in 10 normal healthy subjects aged 20-35 years. Although the interindividual variability in the number of sleep spindles was very high (2.7 +/- 2.1 spindles per minute stage 2 sleep), all but two subjects showed maximal spindle activity in centro-parietal midline leads. Moreover, this topography was seen in all sleep stages and changed only slightly--to a more central distribution--towards the end of the night. On the other hand, slow (11.5-14 Hz) and fast (14-16 Hz) spindles showed a completely different topography, with slow spindles distributed anteriorly and fast spindles centro-parietally. The number of sleep spindles per min was significant depending on sleep stages, with the expected highest occurrence in stage 2, and on recording time, with a decrease in spindle density from the beginning towards the end of the night. However, spindle amplitude, frequency and individual duration was not influenced by sleep depth or time of the night.
应用自动睡眠纺锤波检测程序能够记录纺锤波特征（如数量、振幅、频率和持续时间）的地形图分布，该分布是睡眠深度和记录时间的函数。对10名年龄在20至35岁的正常健康受试者进行了多通道整夜脑电图记录。尽管睡眠纺锤波数量的个体间变异性非常高（在睡眠第二阶段每分钟有2.7±2.1个纺锤波），但除两名受试者外，所有受试者的纺锤波活动在中央顶叶中线导联处均表现为最大值。此外，这种地形图分布在所有睡眠阶段均可见，并且在夜间即将结束时仅略有变化——变为更集中于中央的分布。另一方面，慢纺锤波（11.5 - 14赫兹）和快纺锤波（14 - 16赫兹）呈现出完全不同的地形图分布，慢纺锤波分布在前部，快纺锤波分布在中央顶叶区域。每分钟睡眠纺锤波的数量因睡眠阶段不同而有显著差异，在第二阶段出现频率最高，并且也受记录时间影响，从夜间开始到结束纺锤波密度逐渐降低。然而，纺锤波的振幅、频率和个体持续时间不受睡眠深度或夜间时间的影响。
