Graham P A, Nash A S, McKellar Q A
Department of Veterinary Clinical Studies, University of Glasgow.
J Small Anim Pract. 1997 Oct;38(10):434-8. doi: 10.1111/j.1748-5827.1997.tb03435.x.
Ten dogs with naturally occurring diabetes mellitus were injected with a highly purified porcine insulin zinc suspension at a dose according to their expected requirement. Plasma insulin and glucose concentrations were measured at two-hourly intervals over 24 hours following injection. There were either one or two peaks in plasma insulin concentration: one at about four hours (mean 4.3 +/- 1.3 [SD]) and another at about 11 hours (mean 11 +/- 1.85) after the injection. The second insulin peak was seen in only eight dogs. Persistence of elevated plasma insulin concentrations ranged from 14 to 24 hours (mean 17.4 +/- 3.65). These results compare favourably with those published for other intermediate-acting insulin preparations used to treat canine diabetes mellitus and suggest that this preparation has useful properties for the successful management of many canine diabetics.
十只患有自然发生的糖尿病的狗，按照它们预期的需求量，注射了高纯度猪胰岛素锌混悬液。注射后24小时内，每隔两小时测量血浆胰岛素和葡萄糖浓度。血浆胰岛素浓度出现了一到两个峰值：一个在注射后约4小时（平均4.3±1.3[标准差]），另一个在约11小时（平均11±1.85）。只有八只狗出现了第二个胰岛素峰值。血浆胰岛素浓度升高的持续时间为14至24小时（平均17.4±3.65）。这些结果与用于治疗犬糖尿病的其他中效胰岛素制剂所公布的结果相比具有优势，表明这种制剂对于成功管理许多犬糖尿病患者具有有用的特性。
