Freyer A J, Patil A D, Killmer L, Troupe N, Mentzer M, Carte B, Faucette L, Johnson R K
Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, R & D, King of Prussia, Pennsylvania 19406-0939, USA.
J Nat Prod. 1997 Oct;60(10):986-90. doi: 10.1021/np9701438.
Bioassay-guided fractionation of the MeOH-CH2Cl2 extract of the Micronesian ascidian Pseudodistoma megalarva yielded three new piperidine alkaloids, pseudodistomins D-F (3-5) and the previously reported pseudodistomins B and C (1 and 2). The structure and stereochemistry of these compounds were established by interpretation of spectral data. Pseudodistomins B-F were found to be active in a cell-based assay for DNA damage induction, but the activity was due to an alternative mechanism.
对密克罗尼西亚海鞘巨幼虫甲醇 - 二氯甲烷提取物进行生物测定导向的分级分离，得到了三种新的哌啶生物碱，伪海鞘素D - F（3 - 5）以及先前报道的伪海鞘素B和C（1和2）。这些化合物的结构和立体化学通过光谱数据解析得以确定。发现伪海鞘素B - F在基于细胞的DNA损伤诱导测定中具有活性，但该活性是由另一种机制引起的。
