Chbani M, Païs M, Delauneux J M, Debitus C
Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France.
J Nat Prod. 1993 Jan;56(1):99-104. doi: 10.1021/np50091a014.
Chemical investigation of the cytotoxic CH2Cl2-soluble extract of the marine tunicate Pseudodistoma arborescens led to the isolation of four brominated indole alkaloids, arborescidines A [1], B [2], C [3], and D [4], which were characterized by their spectral data, especially 2D nmr. Only arborescidine D [4] showed moderate activity (IC50 3 micrograms/ml) in vitro against the growth of KB human buccal carbinoma cells.
对海洋被囊动物树状拟双体海鞘的细胞毒性二氯甲烷可溶提取物进行化学研究，从中分离出四种溴化吲哚生物碱，即树状海鞘碱A [1]、B [2]、C [3]和D [4]，通过光谱数据，尤其是二维核磁共振对其进行了表征。只有树状海鞘碱D [4]在体外对KB人颊癌细胞的生长表现出中等活性（IC50为3微克/毫升）。
