普拉基尼定D，一种从双体海鞘属的两种海鞘中分离出的新型吡咯并吖啶生物碱。

Plakinidine D, a new pyrroloacridine alkaloid from two ascidians of the genus Didemnum.

作者信息

Smith C J, Venables D A, Hopmann C, Salomon C E, Jompa J, Tahir A, Faulkner D J, Ireland C M

机构信息

Department of Medicinal Chemistry, University of Utah, Salt Lake City 84112, USA.

出版信息

J Nat Prod. 1997 Oct;60(10):1048-50. doi: 10.1021/np970311w.

DOI:10.1021/np970311w

PMID:9358648

Abstract

A previously undescribed red Didemnum sp. collected in Indonesia contained a novel pyrroloacridine, plakinidine D (4), along with the known compounds 3,5-diiodo-4-methoxyphenethylamine (5) and ascididemin (6), both of which had previously been isolated from ascidians of the genus Didemnum. Plakinidine D (4) and 3,5-diiodo-4-methoxyphenethylamine (5) were also isolated from Didemnum rubeum from the Republic of Palau. Interestingly, a collection of D. rubeum from Indonesia did not contain plakinidine D (4), but instead contained 3,5-diiodo-4-methoxyphenethylamine (5) and ascididemin (6). The structure of plakinidine D (4) was elucidated by analysis of its spectral data. Plakinidine D (4) is closely related to plakinidines A-C (1-3), previously isolated from the sponge Plakortis sp.

摘要

在印度尼西亚采集到一种此前未描述过的红色皮海鞘（Didemnum sp.），从中发现了一种新型吡咯并吖啶——普拉基尼定D（4），以及已知化合物3,5 - 二碘 - 4 - 甲氧基苯乙胺（5）和海鞘胺（6），这两种化合物此前都曾从皮海鞘属的海鞘中分离得到。普拉基尼定D（4）和3,5 - 二碘 - 4 - 甲氧基苯乙胺（5）也从帕劳共和国的红色皮海鞘中分离得到。有趣的是，从印度尼西亚采集的红色皮海鞘样本中不含普拉基尼定D（4），而是含有3,5 - 二碘 - 4 - 甲氧基苯乙胺（5）和海鞘胺（6）。通过对其光谱数据的分析阐明了普拉基尼定D（4）的结构。普拉基尼定D（4）与先前从海绵Plakortis sp.中分离得到的普拉基尼定A - C（1 - 3）密切相关。