Pezzella F, Pastorino U, Tagliabue E, Andreola S, Sozzi G, Gasparini G, Menard S, Gatter K C, Harris A L, Fox S, Buyse M, Pilotti S, Pierotti M, Rilke F
Department of Histopathology, University College London, UK.
Am J Pathol. 1997 Nov;151(5):1417-23.
Neoplastic growth is usually dependent on blood supply, and it is commonly accepted that this is provided by the formation of new vessels. However, tumors may be able to grow without neovascularization if they find a suitable vascular bed available. We have investigated the pattern of vascularization in a series of 500 primary stage I non-small-cell lung carcinomas. Immunostaining of endothelial cells has highlighted four distinct patterns of vascularization. Three patterns (which we called basal, papillary, and diffuse) have in common the destruction of normal lung and the production of newly formed vessels and stroma. The fourth pattern, which we called alveolar or putative nonangiogenic, was observed in 16% (80/500) of the cases and is characterized by lack of parenchymal destruction and absence of both tumor associated stroma and new vessels. The only vessels present were the ones in the alveolar septa, and their presence highlighted, through the whole tumor, the lung alveoli filled up by the neoplastic cells. This observation suggests that, if an appropriate vascular bed is available, a tumor can exploit it and grows without inducing neo-angiogenesis. This could have implications for strategies aimed at inhibiting tumor growth by vascular targeting or inhibition of angiogenesis.
肿瘤生长通常依赖血液供应，人们普遍认为这是通过新血管形成来实现的。然而，如果肿瘤找到合适的血管床，它们可能无需新生血管形成就能生长。我们研究了500例I期原发性非小细胞肺癌的血管化模式。内皮细胞免疫染色突出显示了四种不同的血管化模式。三种模式（我们称为基底型、乳头型和弥漫型）的共同特点是正常肺组织被破坏，以及新生血管和间质的形成。第四种模式，我们称为肺泡型或假定的非血管生成型，在16%（80/500）的病例中观察到，其特征是缺乏实质破坏，且不存在肿瘤相关间质和新血管。仅有的血管是肺泡隔中的血管，它们的存在通过整个肿瘤突出显示了被肿瘤细胞填满的肺泡。这一观察结果表明，如果有合适的血管床，肿瘤可以利用它并在不诱导新生血管生成的情况下生长。这可能对旨在通过血管靶向或抑制血管生成来抑制肿瘤生长的策略产生影响。
