Institute of Pathology, University Clinics of RWTH University, Aachen, Germany.
Institute of Pathology and Molecular Pathology, Helios University Clinic Wuppertal, University of Witten/Herdecke, Witten, Germany.
Angiogenesis. 2024 Aug;27(3):293-310. doi: 10.1007/s10456-024-09910-2. Epub 2024 Apr 5.
In European countries, nearly 10% of all hospital admissions are related to respiratory diseases, mainly chronic life-threatening diseases such as COPD, pulmonary hypertension, IPF or lung cancer. The contribution of blood vessels and angiogenesis to lung regeneration, remodeling and disease progression has been increasingly appreciated. The vascular supply of the lung shows the peculiarity of dual perfusion of the pulmonary circulation (vasa publica), which maintains a functional blood-gas barrier, and the bronchial circulation (vasa privata), which reveals a profiled capacity for angiogenesis (namely intussusceptive and sprouting angiogenesis) and alveolar-vascular remodeling by the recruitment of endothelial precursor cells. The aim of this review is to outline the importance of vascular remodeling and angiogenesis in a variety of non-neoplastic and neoplastic acute and chronic respiratory diseases such as lung infection, COPD, lung fibrosis, pulmonary hypertension and lung cancer.
在欧洲国家，近 10%的住院治疗与呼吸系统疾病有关，主要是 COPD、肺动脉高压、特发性肺纤维化或肺癌等危及生命的慢性疾病。血管和血管生成对肺再生、重塑和疾病进展的贡献已越来越受到重视。肺的血管供应具有双重灌注的特点，即肺循环（公共血管）维持功能性的血气屏障，和支气管循环（私有血管）具有血管生成（即内陷性和发芽性血管生成）和招募内皮祖细胞的肺泡血管重塑的特征。本文旨在概述血管重塑和血管生成在各种非肿瘤和肿瘤性的急性和慢性呼吸系统疾病中的重要性，如肺部感染、COPD、肺纤维化、肺动脉高压和肺癌。
