Bhatnagar S, Costall B, Smythe J W
Department of Physiology, University of California at San Francisco, 94143-0444, USA.
Brain Res. 1997 Aug 22;766(1-2):244-8. doi: 10.1016/s0006-8993(97)00684-7.
We examined the role of the hippocampal cholinergic system, which is known to mediate processes related to fear and anxiety, in the regulation of stress-induced hypothalamic-pituitary-adrenal (HPA) activity. Bilateral intra-hippocampal injections (30 microg per side) of the muscarinic antagonist Scopolamine augmented adrenocorticotropin and corticosterone responses to restraint without altering basal HPA activity compared to vehicle-treated animals. These results suggest that the hippocampal cholinergic system regulates stress-induced HPA activity and may serve to coordinate behavioral and neuroendocrine responses to stress.
我们研究了海马胆碱能系统在应激诱导的下丘脑-垂体-肾上腺（HPA）活动调节中的作用，已知该系统介导与恐惧和焦虑相关的过程。与接受溶剂处理的动物相比，双侧海马内注射毒蕈碱拮抗剂东莨菪碱（每侧30微克）可增强促肾上腺皮质激素和皮质酮对束缚的反应，而不改变基础HPA活动。这些结果表明，海马胆碱能系统调节应激诱导的HPA活动，并可能有助于协调对应激的行为和神经内分泌反应。
