Opolon P, Lavallard M C, Huguet C, Bidallier M, Granger A, Gallot D, Bloch P
Surg Gynecol Obstet. 1976 Jun;142(6):845-53.
In this study, the effects of conventional hemodialysis on experimental hepatic coma have been compared with those of hemodialysis against blood from a normal donor which allows exchanges without mixing of blood. cuprophan and polyacrylonitrile membranes were compared. Cross hemodialysis with a donor resulted in rpompt but transient recovery of consciousness, whichever membrane was used. Cuprophan hemodialysis without donor had no effect. Polacrylonitrile hemodialysis without donor allowed progressive and prolonged improvement in the consciusness level and the electroencephalograms. Therefore, clearance of middle molecular weight substances was more effective than exchange with a donor. Preliminary results in man showed total recovery of consciousness in six of ten patients with acute liver failure and coma and partial recovery from complete grade IV coma to grade II encephalopathy in two patients. These two patients reacted when called by their name by opening their eyes and obeying simple orders.
在本研究中，已将常规血液透析对实验性肝昏迷的作用与利用来自正常供体的血液进行血液透析（这种方法可实现血液交换而不发生血液混合）的作用进行了比较。对铜仿膜和聚丙烯腈膜也进行了比较。无论使用哪种膜，与供体进行交叉血液透析都会导致意识迅速但短暂恢复。无供体的铜仿膜血液透析没有效果。无供体的聚丙烯腈膜血液透析能使意识水平和脑电图逐步且持续改善。因此，清除中分子量物质比与供体进行交换更有效。在人体的初步结果显示，10例急性肝衰竭伴昏迷患者中有6例意识完全恢复，2例从完全的IV级昏迷部分恢复至II级脑病。这两名患者在被呼唤名字时会睁开眼睛并听从简单指令。
