Sawada M, Park C H, Morita T, Shimada A, Umemura T, Haritani M
Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
J Vet Med Sci. 1997 Oct;59(10):947-8. doi: 10.1292/jvms.59.947.
Nude mice were infested with bovine Neospora by intraperitoneal inoculation of the brain and spinal cord from an aborted bovine fetus due to neosporosis. Inoculated mice showed severe emaciation and tetraplegia at about 2 to 4 months post-inoculation. Histopathologically, polyradiculoneuritis and peripheral neuritis were the major findings, and lesions in the central nervous system were located at periventricular and submeningeal areas of the cerebrum or at the white matter around the roots of radices of the spinal cord. These findings may suggest the protozoa inoculated into the abdominal cavity invaded the spinal cord via the spinal nerve and later reached the brain through the cerebrospinal fluid.
通过向裸鼠腹腔接种因新孢子虫病流产的牛胎儿的脑和脊髓，使裸鼠感染牛新孢子虫。接种后的小鼠在接种后约2至4个月出现严重消瘦和四肢瘫痪。组织病理学检查发现，主要病变为多神经根神经炎和周围神经炎，中枢神经系统病变位于大脑脑室周围和脑膜下区域或脊髓神经根周围的白质。这些发现可能表明，接种到腹腔的原生动物通过脊神经侵入脊髓，随后通过脑脊液到达大脑。
