转移的一般机制。

General mechanisms of metastasis.

作者信息

Woodhouse E C, Chuaqui R F, Liotta L A

机构信息

Laboratory of Pathology, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethseda, Maryland 20892, USA.

出版信息

Cancer. 1997 Oct 15;80(8 Suppl):1529-37. doi: 10.1002/(sici)1097-0142(19971015)80:8+<1529::aid-cncr2>3.3.co;2-#.

DOI:10.1002/(sici)1097-0142(19971015)80:8+<1529::aid-cncr2>3.3.co;2-#

PMID:9362419

Abstract

In the present article, the steps involved in the process of tumor metastasis are discussed. Several events are required for malignant cells to leave the primary tumor and proliferate at a distant site: vessel formation (angiogenesis), cell attachment, invasion (matrix degradation, cell motility), and cell proliferation. Molecular mechanisms underlying each of these steps are described. Based on blocking these processes, new anti-metastasis therapies are being developed.

摘要

在本文中，我们讨论了肿瘤转移过程中涉及的步骤。恶性细胞离开原发性肿瘤并在远处部位增殖需要几个过程：血管形成（血管生成）、细胞附着、侵袭（基质降解、细胞运动）和细胞增殖。本文描述了这些过程背后的分子机制。基于对这些过程的阻断，正在开发新的抗转移疗法。