Böhle A S, Kalthoff H
Clinic for General Surgery and Thoracic Surgery, Molecular Oncology Research Division, Christian-Albrechts-University, Kiel, Germany.
Langenbecks Arch Surg. 1999 Apr;384(2):133-40. doi: 10.1007/s004230050183.
During the past decade, the molecular mechanisms in the process of tumor metastases and angiogenesis have become better understood.
The development of metastases requires complex molecular interactions in the detachment of tumor cells from solid tumors, the degradation of the extracellular matrix, escape from apoptosis, locomotion in the extracellular matrix, immunologic escape in the circulation, adhesion to endothelial cells, and extravasation from the circulation at the target site of metastasis and induction of angiogenesis.
The increasing knowledge of these complex mechanisms offers new therapeutic approaches in the treatment of malignant diseases. This article will give an overview of the molecular mechanisms involved in the development of metastases and angiogenesis, and their clinical implications.
在过去十年中，肿瘤转移和血管生成过程中的分子机制已得到更好的理解。
转移的发生需要肿瘤细胞从实体瘤脱离、细胞外基质降解、逃避凋亡、在细胞外基质中移动、在循环中进行免疫逃逸、黏附于内皮细胞、在转移靶位点从循环中渗出以及诱导血管生成等复杂的分子相互作用。
对这些复杂机制的深入了解为恶性疾病的治疗提供了新的治疗方法。本文将概述转移和血管生成发展过程中涉及的分子机制及其临床意义。
